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. 2016 Feb 3;3:15021. doi: 10.1038/mto.2015.21

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Luciferase imaging after intravenous injection of unmodified and 5 kDa PEGylated Ad6-Luc 5 kDa PEGylated. Luciferase activity of nude mice treated with Ad6-Luc and Ad6-Luc 5 kDa PEG compared to the PBS control group at days 1, 4, 7, 14, 28, and 42 after treatment. Nude mice were implanted with 10⁷ human DU145 prostate cancer cells subcutaneously in their right hind flank. When tumor volumes reached 200 mm³, groups of 9 or 10 mice were randomized and administered with a single intravenous dose of 3 × 10¹⁰ vp of the indicated viruses or with PBS. PBS, phosphate-buffered saline.