Table 1. Cohorts used in study.
| Subjects | Diagnosis | Ethnicity | Age mean s.d. | T-test for age | ||
|---|---|---|---|---|---|---|
| Discovery cohort (within-participant changes in suicidal ideation) | 37 | BP=15 MDD=7 SZA=6 SZ=4 PTSD=3 Mood NOS=2 | EA=29 AA=8 Other=0 | 47.25 8.59 | ||
| Independent validation cohort-gene expression (suicide completers) | 26 | NP=13 MDD=8 BP=2 SZ=1 AX=1 Alcoholism=1 | EA=21 AA=4 Other=1 | 40.81 17.47 | T-test for age with discovery cohort 0.114 | |
| Independent validation cohort-CFI-S (suicide completers) | 35 | NP=14 MDD=16 BP=2 SZ=1 AX=1 Alcoholism=1 | EA=29 AA=4 Other=2 | 42.46 17.82 | T-test for age with discovery cohort 0.156 | |
| Independent testing cohort for state (suicidal ideation) | 108 | No SI BP=17 MDD=17 SZA=19 SZ=20 Intermediate SI BP=5 MDD=0 SZA=3 SZ=4 High SI BP=7 MDD=8 SZA=6 SZ=2 | EA=71 AA=36 Other=1 | 47.1 9.6 No SI=47.8 High SI=45.7 | T-test for age between no and high SI 0.554 | T-test for age with discovery cohort P=0.919 |
| Testing cohort for trait (first year hospitalizations for suicidality) | 157 (No Hosp for Suicidality=139 Hosp for Suicidality=18) | No Hosp for Suicidality BP=43 MDD=20 SZA=41 SZ=35 Hosp for Suicidality BP=7 MDD=3 SZA=3 SZ=5 | No hosp for SI EA=90 AA=47 Other=2 Hosp for SI EA=13 AA=5 | 49.6 9.5 No hosp for SI=49.56 Hosp for SI=49.92 | T-test for age between no Hosp for suicidality and Hosp for suicidality 0.886 | T-test for age with discovery cohort 0.149 |
| Testing cohort for trait (all future hospitalizations for suicidality) | 157 (No Hosp for Suicidality=122 Hosp for Suicidality=35) | No Hosp for Suicidality BP=41 MDD=20 SZA=29 SZ=32 Hosp for Suicidality BP=9 MDD=3 SZA=15 SZ=8 | No hosp for Suicidality EA=78 AA=43 Other=1 Hosp for Suicidality EA=25 AA=9 Other=1 | 49.6 9.5 No Hosp for suicidality=49.9 Hosp for suicidality=48.4 | T-test for age between no Hosp for suicidality and Hosp for suicidality 0.436 | T-test for age with discovery cohort 0.149 |
Abbreviations: AX, anxiety disorder nos; BP, bipolar; CFI-S, Convergent Function Information for Suicide; MDD, major depressive disorder; NP, non-psychiatric; PTSD, post-traumatic stress disorder; SZA, schizoaffective; SZ, schizophrenia; SI, suicidal ideation.