Table 2. Top biomarkers for suicidality from discovery, prioritization and validation.
| Gene symbol/gene name | Probesets | Discovery (change) method/score | Prior human genetic evidence | Prior human brain expression evidence | Prior human peripheral expression evidence | Prioritization Total CFG score For suicide | Validation ANOVA P-value | Comment |
|---|---|---|---|---|---|---|---|---|
| SKA2 spindle and kinetochore associated complex subunit 2 | 225686_at | (D) DE/1 AP/1 | Suicide15 | (D) PFC15 | (D) Methylation in blood15 | 9 | 0.006 0.027 | Top Decreased BioM In prioritization from AP and DE |
| IL6 interleukin 6 (interferon, beta 2) | 205207_at | (I) AP/2 | (I) PFC27 Hippocampus28 | (I) CSF29, 30 (D) Blood31 | 8 | 1.44e−08 | Top Increased BioM in Validation from AP | |
| SAT1 spermidine/spermine N1-acetyltransferase 1 | 213988_s_at 210592_s_at 230333_at 203455_s_at | (I) DE/2 DE/1 | Suicide32, 33 | (I) PFC BA4612 | (I) Blood1 | 8 | 1.08e−44 1.24e−40 6.93e−12 3.09e−38 | Top Increased BioM in Prioritization from DE Top biomarker in our previous work |
| SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 211494_s_at 210739_x_at | (I) AP/2 DE/1 | Suicide34 | (D) PFC BA46/1035 | 8 | 5.84e−05 0.002 | Top Increased BioM in Prioritization from AP | |
| JUN jun proto-oncogene | 201464_x_at 213281_at 201466_s_at | (I) DE/1 AP1 | (D) HIP36 | 5 | 2.63e−51 1.02e−41 2.21e−08 | Top Increased BioM in Validation from DE | ||
| MBP myelin basic protein | 225408_at | (D) AP/1 | (I) NAC11 | 5 | 6.74e−10 | Top Decreased BioM in Validation from AP | ||
| CADM1 cell adhesion molecule 1 | 237259_at | (I) DE/4 | 4 | NC | Top Increased BioM in Discovery from DE | |||
| CLIP4 CAP-GLY domain containing linker protein family, member 4 | 219944_at | (D) DE/4 | 4 | NC | Top Decreased BioM in Discovery from DE | |||
| DTNA dystrobrevin, alpha | 211493_x_at | (I) AP/4 | 4 | NC | Top Increased BioM in Discovery from AP | |||
| KIF2C kinesin family member 2C | 211519_s_at | (D) AP/4 | 4 | 0.00056 | Top Decreased BioM in Discovery from AP | |||
| KLHDC3 kelch domain containing 3 | 214383_x_at | (D) DE/4 | (D) Blood1 | 4 | 1.57e−17 | Top Decreased BioM in Validation from DE A top biomarker in our previous study | ||
| MAOB monoamine oxidase B | 204041_at | (I) DE/1 | (I) PFC37 | (D) Blood38 | 7 | 8.11e−08 | Top Pharmacological Target | |
| MARCKS myristoylated alanine-rich protein kinase C substrate | 213002_at 201670_s_at | (I) DE/1 | (I) HIP, PFC39 PFC40 | (I) Blood1 | 5 | 1.51e−06; 0.0004 | A top biomarker in our previous study | |
| PTEN phosphatase and tensin homolog | 204053_x_at 222176_at | (I) DE/1 | (I) PFC, HIP41, 42 | (I) Blood1 | 5 | 7.66e−17; 0.0003 | A top biomarker in our previous study |
Abbreviations: ANOVA, analysis of variance; AP, absent–present; CFG, convergent functional genomics; CSF, cerebrospinal fluid; DE, differential expression; SI, suicidal ideation.
Bolded P-values are Bonferroni significant. NC—Non-concordant-not stepwise from no SI to high SI to suicide completers.