Table 5. Predictions.
|
A. Best predictors | |||||
|---|---|---|---|---|---|
| Predictors ROC AUC/P-value | All participants | BP participants | MDD participants | SZA participants | SZ participants |
| Suicidal ideation cohort N=108 participants | UP-Suicide 0.92/7.94e−15 | UP-Suicide 0.98/ 1.19E-6 | UP-Suicide 0.95/2.96E-7 | UP-Suicide 0.81/0.0018 | Mood 0.94/0.00075 UP-Suicide 0.91/0.0015 |
| First year hospitalizations for suicidality cohort N=157 participants | SASS 0.71/0.0080 UP-Suicide 0.71/0.0094 | SASS 0.95/0.0016 UP-Suicide 0.94/0.0021 | CFI-S 0.78/0.066 UP-Suicide 0.70/0.16 | Anxiety 0.65/0.21 UP-Suicide 0.52/0.47 | UP-Suicide 0.68/0.17 |
|
B. All predictions | |||||
|---|---|---|---|---|---|
| All participants | BP participants | MDD participants | SZA participants | SZ participants | |
| No SI=73 | No SI=17 | No SI=17 | No SI=19 | No SI=20 | |
| Predictors ROC AUC/P-value | Intermediate SI=12 High SI=23 | Intermediate SI=5 High SI=7 | Intermediate SI=0 High SI=8 | Intermediate SI=3 High SI=6 | Intermediate SI=4 High SI=2 |
| Suicidal ideation cohort N=108 participants Biomarkers | SKA2 0.69/0.00018 SLC4A4 0.72/2.41E-5 KIF2C 0.42/0.92 DTNA 0.54/0.22 MBP 0.53/0.30 IL6 0.66/0.0017 SAT1 0.35/1 CLIP4 0.52/0.37 CADM1 0.59/0.045 KLHDC3 0.47/0.72 JUN 0.46/0.76 BIOM6 0.64/0.0042 BIOM5 0.54/0.23 BIOM11 0.63/0.0088 | SKA2 0.76/0.0045 SLC4A4 0.93/9.45E-6 KIF2C 0.33/0.96 DTNA 0.61/0.15 MBP 0.54/0.35 IL6 0.66/0.06 SAT1 0.19/1 CLIP4 0.76/0.0050 CADM1 0.73/0.013 KLHDC3 0.52/0.41 JUN 0.39/0.86 BIOM6 0.69/0.028 BIOM5 0.69/0.029 BIOM11 0.75/0.0070 | SKA2 0.54/0.34 SLC4A4 0.55/0.33 KIF2C 0.52/0.45 DTNA 0.53/0.41 MBP 0.61/0.15 IL6 0.76/0.0057 SAT1 0.39/0.86 CLIP4 0.21/1 CADM1 0.63/0.11 KLHDC3 0.47/0.60 JUN 0.54/0.37 BIOM6 0.72/0.017 BIOM5 0.44/0.73 BIOM11 0.57/0.26 | SKA2 0.68/0.06 SLC4A4 0.64/0.11 KIF2C 0.41/0.78 DTNA 0.53/0.41 MBP 0.43/0.74 IL6 0.58/0.24 SAT1 0.48/0.59 CLIP4 0.54/0.38 CADM1 0.48/0.56 KLHDC3 0.38/0.86 JUN 0.54/0.38 BIOM6 0.61/0.18 BIOM5 0.44/0.69 BIOM11 0.51/0.46 | SKA2 0.82/0.011 SLC4A4 0.76/0.03 KIF2C 0.43/0.71 DTNA 0.45/0.66 MBP 0.58/0.28 IL6 0.62/0.19 SAT1 0.37/0.84 CLIP4 0.61/0.21 CADM1 0.49/0.54 KLHDC3 0.49/0.53 JUN 0.37/0.84 BIOM6 0.49/0.55 BIOM5 0.61/0.21 BIOM11 0.64/0.16 |
| Clinical | Anxiety 0.78/2.3E-7 Mood 0.82/1.62E-9 SASS 0.85/9.96E-11 CFI-S 0.89/3.53E-13 | Anxiety 0.86/0.00018 Mood 0.81/0.00091 SASS 0.87/0.00011 CFI-S 0.97/ 1.75E-6 | Anxiety 0.81/0.0015 Mood 0.81/0.0015 SASS 0.87/6.01E-5 CFI-S 0.95/7.98E-6 | Anxiety 0.75/0.12 Mood 0.77/0.0080 SASS 0.81/0.0019 CFI-S 0.74/0.016 | Anxiety 0.62/0.19 Mood 0.94/0.00075 SASS 0.85/0.0058 CFI-S 0.85/0.0049 |
| Combined | UP-Suicide 0.92/7.94E-15 | UP-Suicide 0.98/1.19E-6 | UP-Suicide 0.95/2.96E-7 | UP-Suicide 0.81/0.0018 | UP-Suicide 0.91/0.0015 |
| All participants | BP participants | MDD participants | SZA participants | SZ participants | |
|---|---|---|---|---|---|
| Predictors ROC AUC/P-value | No Hosp=139 Hosp=18 | No Hosp=43 Hosp=7 | No Hosp=20 Hosp=3 | No Hosp=41 Hosp=3 | No Hosp=35 Hosp=5 |
| First year hospitalizations for suicidality N=157 participants Biomarkers | SKA2 0.44/0.78 SLC4A4 0.47/0.66 KIF2C 0.54/0.30 DTNA 0.44/0.77 MBP 0.38/0.92 IL6 0.48/0.60 SAT1 0.55/0.28 CLIP4 0.31/0.99 CADM1 0.53/0.36 KLHDC3 0.31/0.98 JUN 0.40/0.89 BIOM6 0.51/0.46 BIOM5 0.35/0.96v BIOM11 0.42/0.82 | SKA2 0.71/0.056 SLC4A4 0.70/0.08 KIF2C 0.59/0.26 DTNA 0.61/0.21 MBP 0.30/0.90 IL6 0.45/0.65 SAT1 0.63/0.18 CLIP4 0.26/0.91 CADM1 0.72/0.076 KLHDC3 0.41/0.72 JUN 0.36/0.85 BIOM6 0.62/0.23 BIOM5 0.50/0.52 BIOM11 0.63/0.24 | SKA2 0.048/0.99 SLC4A4 0.048/0.99 KIF2C 0.45/0.61 DTNA 0.29/0.83 MBP 0.42/0.68 IL6 0.76/0.090 SAT1 0.62/0.29 CLIP4 0.25/0.92 CADM1 0.74/0.17 KLHDC3 0.31/0.81 JUN 0.37/0.77 BIOM6 0.68/0.18 BIOM5 0.24/0.88 BIOM11 0.48/0.55 | SKA2 0.41/0.70 SLC4A4 0.37/0.78 KIF2C 0.42/0.67 DTNA 0.13/0.96 MBP 0.29/0.88 IL6 0.28/0.90 SAT1 0.37/0.76 CLIP4 0.31/0.87 CADM1 0.048/0.99 KLHDC3 0.29/0.88 JUN 0.58/0.35 BIOM6 0.14/0.96 BIOM5 0.28/0.90 BIOM11 0.23/0.94 | SKA2 0.13/0.99 SLC4A4 0.39/0.74 KIF2C 0.67/0.19 DTNA 0.46/0.61 MBP 0.53/0.46 IL6 0.55/0.41 SAT1 0.44/0.63 CLIP4 0.41/0.69 CADM1 0.56/0.39 KLHDC3 0.16/0.95 JUN 0.30/0.90 BIOM6 0.43/0.63 BIOM5 0.40/0.72 BIOM11 0.40/0.72 |
| Clinical | Anxiety 0.64/0.066 Mood 0.58/0.16 SASS 0.71/0.0080 CFI-S 0.71/0.0058 | Anxiety 0.69/0.14 Mood 0.70/0.059 SASS 0.95/0.0016 CFI-S 0.86/0.01 | Anxiety 0.52/0.48 Mood 0.60/0.32 SASS 0.77/0.083 CFI-S 0.78/0.066 | Anxiety 0.65/0.21 Mood 0.45/0.63 SASS 0.59/0.31 CFI-S 0.75/0.12 | Anxiety 0.58/0.34 Mood 0.5/0.51 SASS 0.63/0.25 CFI-S 0.54/0.40 |
| Combined | UP-Suicide 0.71/0.0094 | UP-Suicide 0.94/0.0021 | UP-Suicide 0.7/0.16 | UP-Suicide 0.52/0.47 | UP-Suicide 0.68/0.17 |
Abbreviations: AUC, area under curve; BP, bipolar; CFI-S, convergent functional information for suicide; MDD, major depressive disorder; ROC, receiver operating characteristic; SASS, simplified affective state scale; SI, suicidal ideation; SZA, schizoaffective; SZ, schizophrenia; UP, universal predictive measure.
ROC AUC/P-values. UP-Suicide is composed of increased markers (CFI-S, anxiety, BioM-6 panel of increased biomarkers) and decreased markers (mood, BioM-5 panel of decreased biomarkers); SASS is composed of increased marker (anxiety), and decreased marker (mood).