Fig. 3.

Effects of normal and reduced doses on anti-factor Xa activity in rivaroxaban (a) and apixaban (b), and on PT (c) and APTT (d). For rivaroxaban, the blue points indicate the normal dose (15 mg once daily) and the gray points indicate the reduced dose (10 mg once daily). For apixaban, the red points indicate the normal dose (5 mg twice daily) and the yellow points indicate the reduced dose (2.5 mg twice daily). The figure shows the values obtained within 30 h after the administration of the drugs (rivaroxaban, 98 samples; apixaban, 88 samples), 229±231 days after the first administration of rivaroxaban, and 83±91 days after the first administration of apixaban. For rivaroxaban and apixaban, the anti-factor Xa activity of the normal and reduced doses seemed to be on the same time–activity curve. Apparent differences in PT and APTT were not found between the normal and reduced doses of both drugs.