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Clinical course of case B.
| CCr (mL/min) | Anti-factor Xa activity (IU/mL) | PT (s) | APTT (s) | |
|---|---|---|---|---|
| Before | 24.4 | – | 11.0 | 33.3 |
| Apixaban (trough) | ||||
| (14th day) 2.5 mg twice daily | 16.5 | 3.18 | 19.4 | 40.3 |
| (22nd day) 2.5 mg once daily | 17.0 | 1.79 | 14.9 | 37.9 |
| (36th day) 2.5 mg once daily | 15.1 | 1.73 | 14.9 | 38.3 |
| (53rd day) 2.5 mg once for every other day | 6.0 | 2.53 | 16.4 | 41.8 |
