Fig. 5.

The top synergistic and antagonistic drug combinations identified from the Mathews Griner data. (A) The ispinesib and ibrutinib combination. (B) The canertinib and ibrutinib combination. For each combination, the interaction landscapes are shown in both 2D and 3D.δ: the excess % inhibition beyond the expectation by the ZIP model; Δ: the average δ scores over the dose–response matrix. The complete interaction landscapes for all the 466 drug combinations can be found in Supplementary Fig. 3.

The top synergistic and antagonistic drug combinations identified from the Mathews Griner data. (A) The ispinesib and ibrutinib combination. (B) The canertinib and ibrutinib combination. For each combination, the interaction landscapes are shown in both 2D and 3D.δ: the excess % inhibition beyond the expectation by the ZIP model; Δ: the average δ scores over the dose–response matrix. The complete interaction landscapes for all the 466 drug combinations can be found in Supplementary Fig. 3.