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Schematic model of WT1 post-transcriptional regulation of EZH2. A, WT1(+KTS) (red) binds the 5′ UTR of the EZH2 transcript and the miRNA(green)-containing RISC (gray) binds to the 3′ UTR seed sequence (green) to block access of the translation machinery. B, in the absence of WT1(+KTS) and miRNA-containing RISC, the 40S ribosome and translation complexes bind to the EZH2 transcript 5′ UTR and promote protein translation.
