TABLE 3.
Theoretical fragments of the trypsinolysis of the VWF A1 domain sorted by residue sequence
| Fragment | VWF residues | Secondary structure | Sequence |
|---|---|---|---|
| T1 | (−)MR (G) | ||
| T3 | Leu1275–Arg1287 | β1 | (R)LLDLVFLLDGSSR(L) |
| T4 | Leu1288–Lys1297 | α1 | (R)LSEAEFEVLK(A) |
| T5 | Ala1298–Arg1306 | α1 | (K)AFVVDMMER(L) |
| T6 | Leu1307–Arg1308 | α1-loop-β2 | (R)LR(I) |
| T7 | Ile1309–Lys1312 | α1-loop-β2 | (R)ISQK(W) |
| T8 | Trp1313–Arg1315 | β2 | (K)WVR (V) |
| T9 | Val1316–Arg1332 | β2-hairpin-β3 | (R)VAVVEYHD(G→S)SHAYIGLK(D) |
| T10 | Asp1333–Arg1334 | β3-loop-α2 | (K)DR(K) |
| T11 | Lys1335 | α2 | (R)K(R) |
| T12 | Arg1336–Arg1341 | α2 | (K)RPSELR(R) |
| T13 | Arg1342 | α2 | (R)R(I) |
| T14 | Ile1343–Lys1348 | α2 | (R)IASQVK(Y) |
| T15 | Tyr1349–Lys1362 | α2-loop-α3 | (K)YAGSQVASTSEVLK(Y) |
| T16 | Tyr1363–Lys1371 | α3 | (K)YTLFQIFSK(I) |
| T17 | Ile1372–Arg1379 | α3-loop-β4 | (K)IDRPEASR(I) |
| T18 | Ile1380–Arg1392 | β4 | (R IALLLMASQEPQR(M) |
| T19 | Met1393–Arg1395 | β4-loop-α4 | (R)MSR(N) |
| T20 | Asn1396–Arg1399 | α4 | (R)NFVR(Y) |
| T21 | Tyr1400–Arg1405 | α4 | (R)YVQGLK(K) |
| T22 | Lys1406 | α4 | (K)K(K) |
| T23 | Lys1407 | α4 | (K)K(K) |
| T24 | Lys1408 | α4-loop-β4 | (K)K(V) |
| T25 | Val1409–Arg1423 | β5-loop-α5 | (K)VIVIPVGIGPHANLK(Q) |
| T26 | Gln1424-Arg1426 | α5 | (K)QIR(L) |
| T27 | Leu1427–Lys1430 | α5 | (R)LIEK(Q) |
| T28 | Gln1431–Lys1436 | α5-loop-β6 | (K)QAPENK(A) |
| T29 | Ala1437–Arg1450 | β6-loop-α6 | (K)AFVLSSVDELEQQR(D) |
| Disulfide | |||
| T2 | Gln1238–Arg1274 | N terminus and β1 | (R)GSHHHHHHGSQEPGGLVVPPTD |
| APVSPTTLYVEDISEPPLHDFYCSR(L) | |||
| T30 | Asp1451–Arg1472 | α6 and C terminus | (R)DEIVSYLCDLAPEAPPPTLPPD(−) |