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Francisella catalase modulation of macrophage function is mediated by TRPM2. WT and TRPM2−/− murine bone marrow-derived macrophages were examined to determine the contribution of TRPM2 to the immune response to Francisella. Macrophage function as measured by actin polymerization and IL-6 message were decreased in TRPM2-null BMDM following infection with LVSΔKat (A and B). **, p < 0.001; #, p < 0.0001.
