Has2 mRNA was up-regulated despite MEK1 inhibition or basigin knockdown in SF.
A, Has2 mRNA expression in SF in monoculture or direct co-culture after 24 h of treatment with the MEK1 inhibitor PD98059 (n = 6). B, Has2 mRNA expression in SF after transfection with control siRNA and siRNA targeting murine basigin (Bsg) (n = 5). C, Has2 mRNA expression in SF in co-culture with si BSG- or si control-transfected KYSE-410 cells (n = 4). Data are presented as mean ± S.E. (error bars). *, p < 0.05; n.s., not significant.