FIGURE 1.

Icsbp was not required for granulocyte release from the bone marrow during the first phase of emergency granulopoiesis. Icsbp^−/− and wild-type mice were injected with Alum to stimulate emergency granulopoiesis or saline as a steady-state granulopoiesis control. Peripheral blood counts were determined 24 h later. A, granulocytes (PMNs) increased significantly in Icsbp^−/− and WT mice after Alum injection. Statistically significant differences are indicated by *, **, ***, and #. B and C, lymphocytes (B) or monocytes (C) decreased significantly in Icsbp^−/− and WT mice 24 h after Alum injection. Statistically significant differences are indicated by *, **, and ***. p < 0.02 was considered statistically significant.