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Simplified pictorial representation of effects of myozap deficiency on cardiac signaling. Myozap deficiency on the one hand inhibits SRF signaling via inhibition of MAPK ERK1/2, RhoA, and MKL1. On the other hand, it activates prohypertrophic calcineurin-NFAT via inhibition of MAPK p38 and interconnected GSK-3β/β-catenin-driven signaling cascade in response to biomechanical stress. Cn, calcineurin; β-catn, β-catenin.
