FIGURE 2.

Resistance against glucose metabolism dysfunction and maintenance of insulin sensitivity in HFD-fed Prip-KO mice. Twenty-week-old wild-type (WT) and Prip-KO (KO) mice, which were fed a RD or a HFD from 5 weeks of age, were fasted for 12 (A–C) or 4 h (D) before blood sample collection. A, blood glucose concentration in WT (RD, n = 9; HFD, n = 12) and KO (RD, n = 9; HFD, n = 12) mice. B, plasma insulin concentration in WT (RD and HFD, n = 4) and KO (RD and HFD, n = 4) mice. C and D, glucose tolerance test and insulin tolerance test in HFD-fed mice (WT and KO, n = 8). Blood glucose levels were measured after intraperitoneal injection of glucose (C) or insulin (D). Graphs in D show the percentages of initial blood glucose levels. The data represent the mean ± S.E. *, p < 0.05; **, p < 0.01 versus RD (A and B) or WT (C and D); n.s., not significant.