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Kinetic analysis of AML-associated Tet2 mutants. A, SDS-PAGE analysis of purified recombinant Tet2 mutants H1302Y, D1304A, H1802R, R1817M, and R1817S. B and C, Michaelis-Menten curves and a Lineweaver-Burk plot (inset) of Tet2 mutants H1302Y and R1817M for Fe2+ and 2-oxoglutarate, respectively.
