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. 2015 Dec 23;291(8):4256–4265. doi: 10.1074/jbc.M115.688762

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FIGURE 5. — TETs regulate HIF target gene expression. A and B, qPCR analysis of TET1 (A) and TET3 (B) mRNA expression levels in SK-N-BE(2) cells following siRNA knockdown of TET1 (A) or TET3 (B) (n = 3). C and D, HLPC-MS/MS quantitation of global 5-hmC (C) and 5-mC (D) levels in SK-N-BE(2) cells following siRNA knockdown of TET1 or 3 and DEF or DMS treatment (n = 3). E and F, qPCR analysis of VEGFA and HK2 mRNAs following knockdown of TET1 or TET3 and DEF or DMS treatment (n = 3). G, qPCR analysis of BNIP3, PGK1, and ENO1 mRNA expression in SK-N-BE(2) cells following siRNA knockdown of TET1 or TET3 (n = 3). All graphs represent mean ± S.E. *, p < 0.05; **, p < 0.01; ***, p < 0.005.