TABLE 2.

K_m values of Tets 1 and 2 by comparison with HIF-P4H-2 and collagen prolyl 4-hydroxylase I (C-P4H-I) for the substrate, cosubstrates and cofactor

The values are mean ± S.D. of 3 to 7 independent assays.

Compound	Unit	Tet1	Tet2	HIF-P4H-2a	C-P4H-Ib
Methylated DNA substrate	nM	75 ± 55	125 ± 85
Fe2+	μm	4.8 ± 4	3.6 ± 3	0.03 ± 0.004	2
2-Oxoglutarate	μm	55 ± 20	60 ± 15	60	20
Oxygen	μm	30 ± 10	30 ± 3	250	40

^a Refs. 26 and 38.

^b Ref. 39.