Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 24;21(3):364–375. doi: 10.1038/mp.2015.18

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Arc-dVenus⁺ neurons exhibit increased excitability. (a) Superimposed current-clamp recordings with −100, 0, +140, +300 pA sustained current injection at a holding membrane potential of −75 mV. Arc-dVenus⁺ neurons (top) fire more APs than non-activated neighbors (bottom) in naïve, unpaired and paired conditions. Scale bars: 20 mV, 50 ms. (b) Plot of the mean AP count versus current injection intensity for naïve (left), unpaired (center) and paired (right) conditions. Arc-dVenus⁺ neurons (naïve: n=15, unpaired: n=17, paired: n=16; green) show higher excitability compared with neighboring Arc-dVenus⁻ neurons (naïve: n=16, unpaired: n=17, paired: n=18; black). Naïve: n=12 mice, Unpaired: n=6 mice, Paired: n=8 mice. Repeated measures analysis of variance, Arc-dVenus × current intensity interaction: naïve, F=14.06, P<0.001; unpaired, F=3.75, P<0.05; paired, F=3.55, P<0.05. *P<0.05.