Fig. 1.

Continued reduction in symptom and medication scores 2 years after withdrawal of grass pollen immunotherapy is accompanied by persisting IgG4-mediated inhibitory activity against IgE-FAP. a Symptom and medication scores at baseline, after 2 years of allergen immunotherapy and 2 years after stopping treatment. b Inhibition of IgE-FAP by sera taken at baseline, after 2 years of allergen immunotherapy and 2 years after stopping treatment. c Serum grass pollen-specific IgG4 measured by ELISA at baseline, after 2 years of allergen immunotherapy and 2 years after stopping treatment. d Inhibition of IgE-FAP by mock-depleted or IgG4-depleted serum taken after 2 years of allergen immunotherapy. e Inhibition of IgE-FAP by mock-depleted or IgG4-depleted serum taken 2 years after stopping treatment. Figure reproduced with permission from Reference 38