Table 1.

Absolute metabolite concentrations (μmol/g) given as mean ± SEM, in the anterior cingulate cortex following treatment with ebselen (3600 mg over 24 h) or placebo of inositol, N-acetylaspartate (NAA), glutathione (GSH), γ-aminobutyric acid (GABA), glutamate, glutamine, and Glx. The averages of the linewidth (Hz) and signal to noise ratio (SNR) have also been reported

	Placebo	Ebselen	Significance—paired t test
Inositol	7.82 ± 0.15	7.53 ± 0.14	0.028
NAA	10.53 ± 0.23	10.49 ± 0.26	0.789
GSH	1.31 ± 0.043	1.17 ± 0.07	0.033
GABA	2.04 ± 0.08	2.04 ± 0.07	0.984
Glutamate	11.66 ± 0.17	11.34 ± 0.15	0.010
Glutamine	3.60 ± 0.10	3.37 ± 0.10	0.024
Glx	15.26 ± 0.19	14.71 ± 0.18	0.001
Linewidth	9.66 ± 0.53	9.55 ± 0.43	0.743
SNR	39.5 ± 1.4	40.4 ± 1.6	0.264