Table 2.

Biomarkers of treatment with COX-2 inhibitors in schizophrenia.

Subjects Characteristics	Results of Biomarkers
Chronic schizophrenia (n = 25) Healthy normal controls (n = 25)	Plasma levels of IL-2: significantly increased Plasma levels of IL-6: no significantly Correlated to SANS and duration of illness	Kim et al. 2000
Paranoid schizophrenia (n = 24) Healthy normal controls (n = 24)	Serum levels of cytokines (IL-6, IL-8 and IFN-γ): significantly increased Serum levels of IL-2, IL-4 and IFN-α: no significant changes	Kamińska et al., 2001
Schizophrenia (n = 2298) Healthy controls (n = 1858) A research of computerized Literature databases PubMed and EMBASE	Periopheral levels of IL-IRA, sIL-2R and IL-6: significantly increased Periopheral levels of IL-2: significantly deceased Periopheral levels of IFN-γ, IL-4, IL-1RA, IL-2, soluble IL-2receptor and IL-β: no significant changes	Potvin et al., 2008
Schizophrenia (n = 28) Colecoxi 400 mg/day vs. olanzapine	No alterations of blood TNF-alpha and IL-2 levels	Bresee et al., 2006

SANS: The Scale for the Assessment of Negative Symptoms. IL-2, IL-6 and IFN-γ are known as cytokines.