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The putative mechanisms underlying cognitive enhancement by 5-HT1A receptors and Neural network in the prefrontal cortex involving glutamate, GABA, 5-HT and DA neurons. Part of the effect of 5-HT1A agonists on cognition and negative symptoms is thought to be mediated by 5-HT1A receptors located on GABAergic interneurons regulating glutamatergic pyramidal neurons [50, 51, 55].
