Table 2.
Clinical/pathological characteristics of patients with cervical cancer and flotillin-1 expression profile (n = 308)
| Characteristics | N (%) | Expression Level of flotillin-1 | χ2 test P | |
|---|---|---|---|---|
|
|
||||
| Low or non no. (%) | High no. (%) | |||
| Age (years) | 0.788 | |||
| ≤ 40 | 144 (46.8) | 86 (27.9) | 58 (18.8) | |
| > 40 | 164 (53.2) | 106 (34.4) | 58 (18.8) | |
| SCCA (ng/ml)* | 0.727 | |||
| ≤ 1.5 | 191 (66.4) | 124 (43.1) | 67 (23.3) | |
| > 1.5 | 97 (33.7) | 58 (20.1) | 39 (13.5) | |
| FIGO stage | 0.500 | |||
| IB1 | 173 (56.2) | 109 (35.4) | 64 (20.8) | |
| IB2 | 74 (24.0) | 49 (15.9) | 25 (8.1) | |
| IIA1 | 28 (9.1) | 14 (4.5) | 14 (4.5) | |
| IIA2 | 33 (10.7) | 20 (6.5) | 13 (4.2) | |
| Histological type | 308 | 0.082 | ||
| Squamous cell carcinoma | 271 (88.0) | 175 (56.8) | 96 (31.2) | |
| Adenocarcinoma | 21 (6.8) | 9 (2.9) | 12 (3.9) | |
| Adenosquamous | 16 (5.2) | 8 (2.6) | 8 (2.6) | |
| Differentiation grade | 0.636 | |||
| G1 | 21 (6.9) | 12 (3.9) | 9 (2.9) | |
| G2 | 118 (38.6) | 77 (25.2) | 41 (13.4) | |
| G3 | 167 (54.6) | 101 (33.0) | 66 (21.6) | |
| Tumor size, cm | 0.427 | |||
| < 4 | 196 (65.3) | 119 (39.7) | 77 (25.7) | |
| ≥ 4 | 104 (34.7) | 68 (22.7) | 36 (12.0) | |
| Deep stromal Invasion | 0.592 | |||
| No | 135 (45.9) | 87 (29.6) | 48 (1.3) | |
| Yes | 159 (54.1) | 96 (32.7) | 63 (21.4) | |
| Positive parametrium | 0.282 | |||
| No | 301 (97.7) | 189 (61.4) | 112 (36.4) | |
| Yes | 7 (2.3) | 3 (1.0) | 4 (1.3) | |
| Positive surgical margin | 0.896 | |||
| No | 286 (92.9) | 178 (58.8) | 108 (35.1) | |
| Yes | 22 (7.1) | 14 (4.5) | 8 (2.6) | |
| LVSI** | 0.681 | |||
| No | 257 (83.4) | 184 (58.4) | 110 (25.0) | |
| Yes | 51 (16.6) | 8 (3.9) | 6 (12.7) | |
| Lymph node metastasis | < 0.001 | |||
| No | 257 (83.4) | 180 (58.4) | 77 (25.0) | |
| Yes | 51 (16.6) | 12 (3.9) | 39 (12.7) | |
| Recurrence | 0.685 | |||
| No | 266 (86.4) | 167 (70.2) | 99 (29.8) | |
| Yes | 42 (13.6) | 25 (43.9) | 17 (56.1) | |
| Vital status | < 0.001 | |||
| Alive | 274 (88.6) | 183 (59.4) | 91 (29.5) | |
| Death from CC | 34 (11.0) | 9 (2.9) | 25 (8.1) | |
*
SCCA: Squamous cell carcinoma antigen.
**
LVSI: Lymph vascular space involvement.