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Severity of hepatic fibrosis inversely correlates with CTGF gene promoter methylation in vivo. CCl4 was used to induce hepatic fibrosis in 12 rats. A. Histological score was analyzed. B. A correlation test between the severity of hepatic fibrosis and the levels of CTGF gene promoter methylation was analyzed, showing that the severity of hepatic fibrosis inversely correlated with CTGF gene promoter methylation (R=-0.80, p<0.001, n=12). *p<0.05. N=12.
