Figure 3.

Developing eye and sensory placode-derived structures influence the development of surrounding skeletal and other tissues in the head. Upper part (in blue): developing eye influences the formation of surrounding skeleton as evidenced in blind cavefish and observed in the development of a flatfish. Integration of an eye into orbit provides the specie-specific view angle and stands behind stereoscopic vision. Left (in purple): otic vesicle and sensory ear components induce and integrate surrounding cartilage and bone. Lower part (in green): olfactory epithelium development influences formation of surrounding skeletal parts.