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. 2016 Jan 12;20(3):506–517. doi: 10.1111/jcmm.12756

Figure 7.

Figure 7

Pre‐treatment with rPGRN protected against endotoxic shock in WT and Grn −/− mice after LPS injection. Survival of (A) WT mice (n = 8 mice/group) and (B) Grn −/− mice (n = 8 mice/group) with and without rPGRN pre‐treatment. (C and D) Pathological changes in WT and Grn −/− lungs with and without rPGRN pre‐treatment. (E) Production of pro‐inflammatory cytokines in serum of WT and Grn −/− mice with rPGRN pre‐treatment. (F) Western blot analysis of CIRP and HMGB1 in the serum from WT mice with and without rPGRN pre‐treatment. PS red, Ponceau S red staining. (G and H) Apoptosis of lung cells in WT and Grn −/− endotoxic mice with and without rPGRN pre‐treatment. Data are mean ± S.D. *P < 0.05; **P < 0.01; ***P < 0.001 compared with WT or Grn −/− mice injected with LPS.