Table 2. A summary of fluorescent-based thermal shift values against EthR (at 100 μM ligand concentration) and IC50 values determined by SPR for compounds 23, 28 and 29 .
Compound number | Compound structure | ΔT m/°C (100 μM) | IC50/μM (SPR) |
23 |
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+8.7 | >100 |
28 |
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+8.3 | 33 |
29 |
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+9.2 | 52 |