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. 2016 Feb 19;6:21391. doi: 10.1038/srep21391

Figure 1. HFD-induced leukocyte recruitment in the femoral artery and neutrophilia of wt mice.

Figure 1

(a) Leukocyte recruitment in femoral arteries of wt mice fed HFD or NC for 1 (n = 8 and 6, respectively), 2 (n = 8 and 6, respectively), 4 (n = 7 and 8, respectively), or 8 weeks (n = 9 and 8, respectively). Arrowheads show adhesion to the endothelium or rolling leukocytes (left). Bar, 50 μm. Leukocyte recruitment, including leukocyte adhesion and rolling, was significantly increased by HFD for 4 and 8 weeks compared with NC (right). Data are presented as the mean ± SEM. ****P < 0.0001 by two-way ANOVA with Bonferroni’s post test. (b) Leukocyte count (n = 7 and 7, respectively) and proportion of neutrophils (n = 11 and 10, respectively), monocytes (n = 8 and 7, respectively), and lymphocytes (n = 4 and 4, respectively) in peripheral blood of wt mice fed NC or HFD for 4 weeks. Neutrophils of mice fed HFD significantly increased compared with those fed NC. Data are presented as the mean ± SEM. ****P < 0.0001 by unpaired; 2-tailed Student’s t test.