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. 2016 Feb 18;7:10713. doi: 10.1038/ncomms10713

Figure 1. Histological and immunohistochemical findings in 1HR1H4 mutant livers.

Figure 1

Expression of BSEP, MDR3 and FXR in liver (diaminobenzidine chromogen and hematoxylin counterstain) in patients with NR1H4-related cholestasis; normal controls in insets. Hematoxylin/eosin views for orientation. Original magnification, all images, × 200. BSEP and FXR are absent in all four patients when compared with positive control (inset). MDR3 is present in all four patients although reduced in patients 2 and 4. H&E, hematoxylin and eosin.