Figure 3.

Analysis of endothelium, lumen area, and vacuolation in young adult and aged mice. (a and b) Histograms show that endothelial and microvessel lumen areas were significantly increased in both age groups 72 h after stroke. (c) In both young adult and aged mice, stroke significantly increased vacuole formation in the endothelium relative to control capillaries. Vacuoles are expressed as # vacuoles per 10 µm of the vascular endothelium circumference. The number in each histogram bar represents the number of capillaries analyzed per group, sampled from three to five mice per group. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 relative to controls.