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. 2015 Oct 6;36(2):340–362. doi: 10.1177/0271678X15608644

Figure 2.

Figure 2.

Localization of selected membrane proteins at the luminal and abluminal sides of brain microvessel endothelial cells. The luminal and abluminal membrane domains are separated by tight junctions. The sizes of the receptors and their respective domains are not drawn in scale. For details see tables 1 and 2. Orange arrows indicate direction of secretion; dashed orange arrows indicate direction of transport. ABCB1, ABCC4, ABCG2: ABC-binding cassette transporters; OAT3: organic anion transporter 3; Tfr: transferrin receptor; γGT: gamma-glutamyl-transferase; AP: alkaline phosphatase; S1PR1: sphingosine-1-phosphate receptor 1; S1PR3: sphingosine-1-phosphate receptor 3; VEGFR1: vascular endothelial growth factor receptor 1; VEGFR2: vascular endothelial growth factor receptor 2; IL-6: interleukin-6; CXCL12: C-X-C motif chemokine 12 = stromal cell-derived factor 1 (SDF-1); ApoER2: apolipoprotein E receptor 2 = low-density lipoprotein receptor-related protein 8 (LRP8); MCT1: monocarboxylate transporter 1; LAT1: large neutral amino acids transporter; GLUT1: facilitated glucose transporter member 1.