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. 2015 Oct 23;36(2):426–441. doi: 10.1177/0271678X15609939

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© The Author(s) 2015

This article is distributed under the terms of the Creative Commons Attribution 3.0 License ( http://www.creativecommons.org/licenses/by/3.0/ ) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage ).

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Figure
4. — The effect of small molecules identified by qHTS on SUMO conjugation and Ubc9 levels in E18 rat cortical neurons. (a) Representative immunoblots of high molecular weight (>100 kDa) SUMO-1 and SUMO-2,3 conjugates and the Ubc9 conjugase in the total cell lysates from rat E18 primary cortical neurons treated with various compounds with the indicated concentrations for 13.5 h. (b) Quantitative analyses of the conjugates and Ubc9 from three independent experiments. Data represent the mean+/−standard deviation of three independent experiments. **p < 0.01, *p < 0.05 compared to DMSO control.