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. 2015 Dec 11;4(12):720–727. doi: 10.1002/psp4.12045

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© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Numerical simulation of Experiment 2 (Supplementary Table S2). Simulations are the result of the interaction model. The five arms to this experiment are as follows: control (black), sunitinib monotherapy (blue), irinotecan monotherapy (red), and two combination protocols. Group 4 (green) involves sunitinib being given once daily for 12 days, with a single dose of irinotecan at day 2. Group 5 (orange) involves sunitinib being given once daily for 12 days, with a single dose of irinotecan at day 15.