Table 1.

Mean live flea counts and efficacy relative to placebo at 8 h after treatment and post treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

Treatment		Day of treatment or re-infestation
		0	7	14	21	28	35
Placebo	Range	44–99	51–91	69–89	55–92	62–97	75–100
	A. mean	69.9	74.9	77.0	79.8	79.1	87.5
	G. mean1	68.1a	73.3a	76.6a	78.8a	78.4a	87.1a
Sarolaner	Range	0–0	0–3	0–0	0–0	0–8	0–5
	A. mean	0.0	0.4	0.0	0.0	1.6	0.6
	Efficacy (%)	100	99.5	100	100	97.9	99.3
	G. mean1	0.0c	0.2c	0.0c	0.0c	1.0c	0.3c
	Efficacy (%)	100	99.7	100	100	98.8	99.7
	P-value vs. placebo	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
Afoxolaner	Range	0–2	0–35	0–31	0–44	3–66	0–71
	A. mean	0.6	6.1	10.1	15.3	27.5	25.0
	Efficacy (%)	99.1	91.8	86.9	80.9	65.2	71.4
	G. mean1	0.4b	2.4 b	6.8b	8.5b	18.6b	11.3b
	Efficacy (%)	99.4	96.7	91.1	89.2	76.3	87.0
	P-value vs. placebo	<0.0001	<0.0001	<0.0001	<0.0001	0.0005	0.0005
	P-value vs. sarolaner	0.0499	0.0094	<0.0001	<0.0001	<0.0001	<0.0001

¹Geometric means within columns with the same superscript are not significantly different (P > 0.05)