. 2016 Feb 19;9:90. doi: 10.1186/s13071-016-1372-1

Table 3.

Mean live flea counts and efficacy relative to placebo at 24 h after treatment and post treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

Treatment		Day of treatment or re-infestation
Treatment		0	7	14	21	28	35
Placebo	Range	36–87	28–88	48–87	53–73	43–73	58–83
	A. mean	56.5	59.3	64.3	66.3	59.8	71.4
	G. mean¹	54.6^a	56.6^a	62.7^a	66.0^a	59.0^a	70.8^a
Sarolaner	Range	0–0	0–1	0–0	0–0	0–0	0–0
	A. mean	0.0	0.1	0.0	0.0	0.0	0.0
	Efficacy (%)	100	99.8	100	100	100	100
	G. mean¹	0.0^b	0.1^b	0.0^b	0.0^b	0.0^b	0.0^b
	Efficacy (%)	100	99.8	100	100	100	100
	P-value vs.placebo	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
Afoxolaner	Range	0–0	0–0	0–0	0–0	0–0	0–0
	A. mean	0.0	0.0	0.0	0.0	0.0	0.0
	Efficacy (%)	100	100	100	100	100	100
	G. mean¹	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b
	Efficacy (%)	100	100	100	100	100	100
	P-value vs. placebo	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
	P-value vs. sarolaner	1.000	0.5043	1.000	1.000	1.000	1.000

¹Geometric means within columns with the same superscript are not significantly different (P > 0.05)