Table 5.

R calculations based on models with expected/observed fraction and final size.

group no.	vaccine strain	challenge strain	model with expected fraction		model with observed fraction		estimated R
			fraction	R	fraction	R	interval data	final size
high vaccine dose
1	H5N1 R65	H5N1 R65	1	0.12 (0.017–0.795)	1	0.12 (0.017–0.795)	0	0 (<1.64)
2	R65-P18	H5N1 R65	1	0.12 (0.017–0.795)	1	0.12 (0.017–0.795)	0.32 (0.04–2.74)	0.38 (0.01–3.22)
3	R65-P30	H5N1 R65	1	0.12 (0.017–0.795)	1	0.12 (0.017–0.795)	0.38 (0.05–2.69)	0.38 (0.01–3.22)
4	unvaccinated	H5N1 R65	0	6.63 (1.06–41.5)	0	6.63 (1.06–41.47)	∞	∞ (0.84<)
low vaccine dose
5	H5N1 R65	H5N1 R65	0.755113	1.71 (0.272–10.756)	0.3	4.68 (0.747–29.268)	∞	∞ (0.84<)
6	R65-P30	H5N1 R65	0.697442	2.09 (0.333–13.102)	0.6	2.72 (0.434–17.065)	0.25 (0.02–3.43)	0.38 (0.01–3.22)
7	H5N2	H5N1 R65	0.262287	4.92 (0.786–30.801)	0	6.63 (1.06–41.47)	∞	∞ (0.84<)
8	unvaccinated	H5N1 R65	0	6.63 (1.06–41.5)	0	6.63 (1.06–41.47)	1.51 (0.15–14.85)	∞ (0.84<)
9	t/T-P42	H5N1 t/T	0.732831	1.86 (0.296–11.662)	0.8	1.42 (0.226–8.93)	0	0 (<1.64)
10	H5N1 t/T	H5N1 t/T	0.755113	1.71 (0.272–10.756)	0.9	0.77 (0.121–4.863)	0	0 (<1.64)
11	unvaccinated	H5N1 t/T	0	6.63 (1.06–41.5)	0	6.63 (1.06–41.47)	∞	∞ (0.84<)
group combinations
5 and 10	homologous (low dose)		0.755113	1.71 (0.272–10.756)	—	—	0.32 (0.13–0.77)	1.47 (0.30–3.44)
4,8,11	unvaccinated		0	6.63 (1.06–41.5)	—	—	4.60 (1.39–15.2)	∞ (1.99<)