Table 1.
Micronucleus frequency and cytosolic and mitochondrial superoxide concentrations in human neuroblastoma SH-SY5Y cells after combined exposure to sham MF treatment and menadione (MQ). p-Values are given for the effects of the two factors (sham, MQ) and their interaction. The values presented here are mean ± s.e.m.
| MQ concentration (μM) |
p-values from factorial ANOVA |
|||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 5 | 10 | 20 | sham | MQ | sham × MQ | |
| micronuclei (%) | ||||||||
| control | 0.29 ± 0.07 | 0.28 ± 0.08 | 0.32 ± 0.06 | 0.42 ± 0.05 | 0.52 ± 0.03 | 0.200 | 0.004 | 0.965 |
| sham | 0.35 ± 0.04 | 0.35 ± 0.07 | 0.32 ± 0.07 | 0.51 ± 0.09 | 0.57 ± 0.05 | |||
| cytosolic superoxide (RFU) | ||||||||
| control | 183 ± 11 | 191 ± 21 | 168 ± 11 | 183 ± 21 | 187 ± 11 | 0.070 | 0.915 | 0.951 |
| sham | 203 ± 12 | 196 ± 17 | 198 ± 14 | 199 ± 18 | 206 ± 6 | |||
| mitochondrial superoxide (RFU) | ||||||||
| control | 1759 ± 43 | 1565 ± 135 | 1691 ± 88 | 1549 ± 105 | 2083 ± 304 | 0.585 | 0.024 | 0.977 |
| sham | 1888 ± 43 | 1693 ± 57 | 1725 ± 109 | 1481 ± 176 | 2165 ± 352 | |||