Table 2.
Micronucleus frequency and cytosolic and mitochondrial superoxide concentrations in rat C6 glioma cells after combined exposure to sham MF treatment and menadione (MQ). p-Values are given for the effects of the two factors (sham, MQ) and their interaction. The values presented here are mean ± s.e.m.
| MQ concentration (μM) |
p-values from factorial ANOVA |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 5 | 10 | 15 | 20 | 50 | sham | MQ | sham × MQ | |
| micronuclei (%) | ||||||||||
| control | 3.88 ± 0.62 | 3.68 ± 1.09 | 4.50 ± 1.00 | 5.32 ± 1.57 | 5.79 ± 1.72 | 7.55 ± 1.60 | 0.744 | 0.010 | 0.992 | |
| sham | 3.97 ± 0.41 | 3.63 ± 0.82 | 4.32 ± 1.02 | 5.49 ± 1.49 | 5.67 ± 0.77 | 6.51 ± 2.03 | ||||
| cytosolic superoxide (RFU) | ||||||||||
| control | 92 ± 9 | 83 ± 8 | 79 ± 4 | 83 ± 4 | 95 ± 16 | 119 ± 20 | 86 ± 17 | 0.454 | 0.211 | 0.998 |
| sham | 86 ± 11 | 91 ± 10 | 93 ± 11 | 90 ± 14 | 101 ± 22 | 130 ± 27 | 91 ± 28 | |||
| mitochondrial superoxide (RFU) | ||||||||||
| control | 644 ± 86.1 | 474 ± 132 | 579 ± 89.3 | 466 ± 157 | 575 ± 131 | 395 ± 87 | 746 ± 122 | 0.170 | 0.026 | 0.994 |
| sham | 735 ± 97 | 610 ± 95 | 692 ± 98 | 501 ± 97 | 571 ± 16 | 479 ± 56 | 816 ± 36 | |||