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. 2016 Feb 19;6:3. doi: 10.1186/s13395-016-0073-y

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© Kim et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunolabelling of α- and β-dystroglycan, dystrophin and perlecan. a Transverse sections through the TA and EDL at E15.5 and P0 immunolabelled for α- (A-D) and β-dystroglycan (E-H), dystrophin (Mandys1, I-L) and perlecan (M-P). α-dystroglycan (IIH6) showed a clear delineation of the basement membrane around clusters of primary and secondary myotubes at E15.5 (A) and individual muscle fibres at P0 (C), although some clusters are still evident. There was an almost total absence of IIH6 in the FKRP^KD at both time points (B,D). Residual staining of the neuromuscular junction in the FKRP^KD at P0 is shown in D as an inserted image. β-dystroglycan, dystrophin and perlecan immunolabelling were not markedly different between FKRP^KD and wild type at either time point (E-P)