Table 1.
Summary of pathogenic triad features of bacterial meningitis.
 |
Bacterial invasion across the BBB | PMN.migration across the BBB | NF-κB Activation | References |
|---|---|---|---|---|
| S. agalactiae (GBS) S. pneumoniae | ACP NanA | Pial venules Choroid plexus EC | LTA and LPT through TLR2. PLY through TLR4 | Barreiro et al., 2008; Wittchen, 2009; Hanke and Kielian, 2011; Feng et al., 2014; Landwehr-Kenzel and Henneke, 2014; Simonsen et al., 2014 |
| E. coli | GimA | Vim | Vim and PSF | Lee et al., 2005; Che et al., 2011 |
| N. meningitidis | Type IV pili NadA | Ezrin and moesin. Neisseria-containing vacuole | Unclear | Abbruscato et al., 2002; Carman and Springer, 2004; Muller, 2011; Coureuil et al., 2012 |
| L. monocytogenes | InlA and InlB | Unclear | Nod1 and InI B | Opitz et al., 2006; Gründler et al., 2013; Koopmans et al., 2013 |
| M. tuberculosis | VEGF/Hsp65 | ILPs structure | NAC and LTA | Hsieh et al., 2010; Dimasi et al., 2013; Zucchi et al., 2013; Francisco et al., 2015 |