Table 1.
Comparison of demographic and clinical variables between primary sclerosing cholangitis patients with ulcerative colitis and Crohn’s disease (for liver-related outcomes)
| Variable | PSC with CD | PSC with UC | P-value |
|---|---|---|---|
| n = 50 | n = 223 | ||
| Age at diagnosis of PSC (years, mean ± SD) | 37.8 ± 13.1 | 38.3 ± 13.1 | 0.73 |
| Male (n, %) | 30 (60.0%) | 153 (68.6%) | 0.24 |
| Body mass index [g/m2, median (interquartile range)] | 26.4 (22.1–28.8) | 25.0 (22.3–28.1) | 0.56 |
| Smoker (n, %) | 0.02 | ||
| Yes | 6 (12.0%) | 8 (3.6%) | |
| Ex-smoker | 6 (12.0%) | 21 (9.4%) | |
| Alcohol (n, %) | 0.008 | ||
| Yes | 8 (16.0%) | 27 (12.1%) | |
| Ex-alcohol use | 2 (4%) | 5 (2.2%) | |
| Bile duct involvement (n, %) | 0.08 | ||
| Intrahepatic only | 8 (16%) | 48 (21.5%) | |
| Extrahepatic only | 10 (20%) | 27 (12.1%) | |
| Intra-and extrahepatic | 32 (64%) | 148 (66.4%) | |
| Initial albumin [mg/dL, median (range)] | 3.5 (0–5) | 3.6 (1.6–5.2) | 0.73 |
| Initial bilirubin [mg/dL, median (range)] | 1.4 (0–11.2) | 2 (0.2–25.8) | 0.47 |
| Initial INR [median (range)] | 1.0 (0–2.3) | 1.0 (0.7–5.2) | 0.11 |
| Initial PSC Mayo risk score [median (range)] | 1.06 (-2–3.43) | 0.97 (-2.33–5.19) | 0.41 |
| Initial AST [IU/L, median (range)] | 58 (0–278) | 59 (9–691) | 0.42 |
| OLT during follow-up (n, %) | 22 (44.0%) | 99 (44.4%) | 0.96 |
| Age at OLT (years, median) | 42 | 46 | 0.11 |
PSC = primary sclerosing cholangitis; UC = ulcerative colitis; CD = Crohn’s disease; OLT = orthotropic liver transplantation; SD = standard deviation; INR = international normalized ratio; AST = aspartate aminotransferase; OLT = orthotropic liver transplantation