Table 3.

Univariate analysis of risk factors for colectomy

Variable	Odds ratio (95% CI)	P-value
Age	0.86 (0.6 − 1.23)	0.41
Male Gender	1.12 (0.77 − 1.62)	0.55
Serum albumin at diagnosis (>3.6 g/dL)	1.57 (1.09 − 2.25)	0.014
Serum bilirubin at diagnosis	0.41 (0.28 − 0.6)	<0.001
AST	0.64 (0.45 − 0.92)	0.015
Age of diagnosis of UC or CD	0.55 (0.38 − 0.79)	0.001
Duration of UC or CD prior to PSC diagnosis	2.92 (1.98 − 4.29)	<0.001
Age of diagnosis with PSC	0.89 (0.62 − 1.27)	0.52
UDCA use	1.07 (0.69 − 1.63)	0.77
Requirement for OLT	0.36 (0.24 − 0.53)	<0.001
Mayo PSC risk score	0.51 (0.35 − 0.73)	<0.001
5-Aminosalicylate use	1.15 (0.79 − 1.66)	0.47
Azathioprine/6-mercaptopurine use	1.99 (1.2 − 3.29)	0.006
Number of disease flares	4.37 (2.91 − 6.55)	<0.001
Presence of dysplasia/cancer	4.79 (3.33 − 6.88)	<0.001
Colon cancer	5.18 (3.21 − 8.36)	<0.001
CD (relative to UC)	0.6 (0.36 − 1.02)	0.06

AST = aspartate aminotransferase; UC = ulcerative colitis; CD = Crohn’s disease; PSC = primary sclerosing cholangitis; UDCA = ursodexoxycholic acid; OLT = orthotropic liver transplantation