Table 1.

Predictors of an unfavorable response to treatment with peginterferon and ribavirin

Viral Factors

High pre-treatment HCV RNA load

(genotype 1)

Host Factors

Unfavorable IL-28B genotype (e.g. T/T)

African American ethnicity

Male gender

Age > 40 years

Obesity

Steatosis

Insulin resistance

Presence of liver fibrosis

HIV co-infection

Non-compliance with the treatment