Table 1.
Top 15 Intein-Containing Proteins in Bacteria.
| Protein | Number of Inteins | COG (category) | Description: Full Name | Distribution |
|---|---|---|---|---|
| DnaB | 317 | COG0305 (L) |
Replicative DNA helicase (P-loop NTPase) |
Actinobacteria, Aquificae, Bacteroidetes, Chloroflexi, Cyanobacteria, Deinococcus–Thermus, Firmicutes, Gemmatimonadetes, Ignavibacteriae, Proteobacteria |
| RNR | 211 | COG0209 (F) | Ribonucleotide reductase | Acidobacteria, Actinobacteria, Aquificae, Armatimonadetes, Bacteroidetes, Chlorobi, Chloroflexi, Cyanobacteria, Deinococcus–Thermus, Firmicutes, Fusobacteria, Nitrospirae, Proteobacteria, Spirochetes, Synergistetes, Thermodesulfobacteria |
| PolIIIα | 116 | COG0587 (L) | DNA polymerase III alpha subunit | Acidobacteria, Actinobacteria, Aquificae, Bacteroidetes, Cyanobacteria, Deinococcus–Thermus, Firmicutes, Proteobacteria, Planctomycetes |
| RecA | 56 | COG0468 (L) |
Recombination protein (P-loop NTPase) |
Actinobacteria, Cyanobacteria, Proteobacteria |
| GyrA | 50 | COG0118 (L) | DNA gyrase, subunit A | Actinobacteria, Aquificae, Chloroflexi, Proteobacteria |
| SplB | 48 | COG1533 (L) | DNA repair photolyase or spore photoproduct lyase | Actinobacteria |
| GyrB | 33 | COG0187 (L) | DNA gyrase, subunit B | Actinobacteria, Chloroflexi, Cyanobacteria, Proteobacteria |
| RtcB | 27 | COG1690 (J) | tRNA-splicing ligase | Actinobacteria, Aquificae, Bacteroidetes, Cyanobacteria, Deinococcus–Thermus |
| TSase | 21 | COG1351 (F) | Thymidylate synthase | Actinobacteria, Cyanobacteria |
| PhoH | 21 | COG1702 (T) |
Phosphate starvation-inducible protein (P-loop NTPase) |
Actinobacteria, Deinococcus–Thermus |
| UvrD | 16 | COG0210 (L) | DNA-dependent ATPase I and helicase II (P-loop NTPase) | Acidobacteria, Actinobacteria, Deinococcus–Thermus, Firmicutes, Proteobacteria |
| PolIIIγ | 15 | COG2812 (L) | DNA polymerase III tau and gamma subunits (P-loop NTPase) | Cyanobacteria |
| HepA | 15 | COG0553 (KL) | SNF2 superfamily II DNA/RNA helicase | Actinobacteria, Bacteroidetes, Cyanobacteria, Deinococcus–Thermus, Verrucomicrobia |
| DnaG | 14 | COG0358 (L) | DNA primase | Actinobacteria, Proteobacteria |
| RecG | 12 | COG1200 (L) |
ATP-dependent DNA helicase (P-loop NTPase) |
Actinobacteria |