Figure 1.

GISTIC-defined CNAs in LBCL subtypes. (A-B) GISTIC-defined recurrent CNAs (amplification in [A], red; deletions in [B], blue) in 180 primary DLBCLs¹⁴ are compared with those in 11 PMBLs (left panel) and 28 PCNSLs/PTLs (right panel) in mirror plots. Chromosome position is on the y-axis, and significance is on the x-axis. The green line denotes q value of 0.25. (C) Frequencies of the 21 GISTIC-defined amplification peaks (top panel, red) and the 26 GISTIC-defined deletion peaks (bottom panel, blue) in the respective LBCL subtypes are plotted as bar graphs. DLBCL-GCB and DLBCL-ABC are subsets of DLBCL-All. CNAs that are more frequent in PTL and PCNSL (a), PTL only (b), PMBL and PTL (c), and PCNSL only (d), respectively, are noted. CNAs that are significantly enriched in PMBL, PCNSL, and/or PTL are boxed (FDR q value < 0.3; see also supplemental Table 2). Top genes by integrative analyses of copy number (CN) and transcript abundance are indicated on the right.