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. Author manuscript; available in PMC: 2016 Feb 19.
Published in final edited form as: J Proteome Res. 2015 Jul 23;14(9):3519–3529. doi: 10.1021/acs.jproteome.5b00498

Figure 4.

Figure 4

I-TASSER predicted structures of (a) first domain of HIF1A canonical and isoform 3 proteins. RMSD between the two predicted structures was 1.88 Å. The arrow points to the predicted NGR motif unique to HIF1A isform 3. (b) I-TASSER predicted structures of KLC1 canonical, and the isoform 2 proteins were aligned and superimposed using TM-align. Even though the two protein sequences differ at the c-terminal end, the superimposed structures reveal no structural differences. The overall RMSD between the two structures was 2.52 Å. Superimposed structures of the c-terminal ends (500–573 aa for KLC1 canonical protein and 500–560 aa for KLC1 isoform c) showed structural alignment differences at PDGG residues (534–537 aa).