Table 3.

Nonhematologic AEs observed in at least 20% of patients in any arm

	Prior IMiD				Prior BTZ + IMiD				≥2 prior regimens including BTZ and an IMiD
	PAN-BTZ-Dex (n = 241)		Pbo-BTZ-Dex (n = 239)		PAN-BTZ-Dex (n = 92)		Pbo-BTZ-Dex (n = 99)		PAN-BTZ-Dex (n = 72)		Pbo-BTZ-Dex (n = 73)
AE, n (%)	All	Grade 3/4	All	Grade 3/4	All	Grade 3/4	All	Grade 3/4	All	Grade 3/4	All	Grade 3/4
Diarrhea	167 (69)	63 (26)	97 (41)	19 (8)	67 (73)	28 (30)	46 (47)	13 (13)	55 (76)	24 (33)	34 (47)	11 (15)
Fatigue/asthenia	144 (60)	61 (25)	93 (39)	28 (12)	55 (60)	23 (25)	44 (44)	12 (12)	43 (60)	19 (26)	36 (49)	10 (14)
Peripheral neuropathy	149 (62)	41 (17)	160 (67)	34 (14)	51 (55)	14 (15)	52 (53)	9 (9)	42 (58)	12 (17)	39 (53)	5 (7)
Nausea	89 (37)	14 (6)	54 (23)	2 (1)	35 (38)	8 (9)	21 (21)	1 (1)	27 (38)	8 (11)	16 (22)	1 (1)
Peripheral edema	70 (29)	4 (2)	48 (20)	0	18 (20)	2 (2)	18 (18)	0	16 (22)	2 (3)	11 (15)	0
Vomiting	65 (27)	17 (7)	32 (13)	4 (2)	24 (26)	6 (7)	10 (10)	2 (2)	18 (25)	4 (6)	7 (10)	2 (3)
Hypokalemia	65 (27)	47 (20)	30 (13)	11 (5)	24 (26)	19 (21)	17 (17)	6 (6)	18 (25)	15 (21)	12 (16)	5 (7)
Decreased appetite	62 (26)	6 (3)	30 (13)	3 (1)	21 (23)	1 (1)	13 (13)	0	16 (22)	1 (1)	10 (14)	0
Upper respiratory tract infection	60 (25)	7 (3)	40 (17)	4 (2)	30 (33)	4 (4)	17 (17)	0	21 (29)	4 (6)	12 (16)	0
Pyrexia	62 (26)	3 (1)	34 (14)	5 (2)	14 (15)	0	13 (13)	3 (3)	10 (14)	0	10 (14)	3 (4)
Constipation	59 (25)	3 (1)	73 (31)	3 (1)	25 (27)	2 (2)	32 (32)	2 (2)	19 (26)	2 (3)	20 (27)	2 (3)
Cough	54 (22)	1 (0.4)	46 (19)	0	22 (24)	0	20 (20)	0	19 (26)	0	15 (21)	0
Abdominal pain	40 (17)	5 (2)	28 (12)	3 (1)	21 (23)	2 (2)	11 (11)	2 (2)	17 (24)	1 (1)	8 (11)	2 (3)