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Inactivation of activinB rescues the loss of maturity seen in βMen1 insulinomas. Immunofluorescent colocalization of insulin and mature β-cell markers MafA (A), Nkx6.1 (B), Pdx1 (C), Glut2 (D), and Pax4 (E) in Ins− βMen1 and InhβB-βMen1 tumors developed at the age of 14 months is shown. Lower panels are magnified views of each separate marker fluorescent channel.
