FIG 13.

Comparison of hGRβ-specifically regulated genes in the livers of wild-type and GRLKO mice. Two-month-old wild-type and GRLKO mice were injected with PBS (n = 8), AAV-GFP (n = 8), and AAV-hGRβ (n = 8). The total RNA isolated from each group 1 month after injection was applied to an Agilent whole-mouse one-color array. (A) Venn diagrams of hGRβ-specifically regulated genes in wild-type and GRLKO mice. Only 257 genes overlapped. The unique hGRβ-regulated genes in wild-type and GRLKO mice numbered 1,659 and 1,413, respectively. (B) Ingenuity pathway analysis predicted the top diseases and disorders of hGRβ-regulated common genes (257). (C) Ingenuity pathway analysis predicted the top diseases and disorders of hGRβ-regulated unique genes in wild-type mice (1,659). (D) Ingenuity pathway analysis predicted the top diseases and disorders of hGRβ-regulated unique genes in GRLKO mice (1,413).