FIG 4.

Genome-wide microarray analysis of livers from wild-type C57BL/6 mice expressing hGRβ. The total RNA isolated from each group of C57BL/6 was applied to an Agilent whole-mouse one-color array. (A) Venn diagrams of AAV-GFP-regulated genes (left) and AAV-hGRβ-regulated genes (right). The common part (192 genes) likely reflects AAV backbone effect. The unique part (1,916 genes) of AAV-hGRβ represents hGRβ-regulated genes, about 90% of which are upregulated (up arrow). (B) Ingenuity pathway analysis predicted the top biological functions of hGRβ-regulated genes.